NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA, Vasculitides)
1 SST/2.0 mL serum. After 30 minutes of clotting, promptly centrifuge and refrigerate serum. (Includes evaluation for P-ANCA, C-ANCA and atypical P-ANCA)
Room Temp 7 days; Refrigerated: 14 days; Frozen 30 days
Within 3 days/Set Up: Tues-Sat a.m.
C-ANCA are present in 84-100% of patients with generalized Wegener granulomatosis (WG). C-ANCA-positive sera containing PR-3 Abs are 80% sensitive and 97% specific for WG. Positive ANCA results obtained in patients with other types of vasculitis typically give a PANCA pattern and are usually associated with autoantibodies to myeloperoxidase (MPO).