Specimen Requirements

Title

ALPHA-1 -ANTITRYPSIN, QUANTITATIVE

Specimen Requirement

1SST/1.0 mL serum. After 30 minutes of clotting, promptly centrifuge and refrigerate.

Methodology

Stability

Room Temp: 2 days; Refrigerated: 7 days

Reference Range

By report*

Turnaround

2-3 days Setup Mon-Fri PM

Clinical Use

Detection of hereditary diseases in the production of alpha-1- antitrypsin (AAT). Decreased or nearly absent levels of AAT can be a factor in chronic obstructive lung disease and liver disease. An increased prevalence of non-MM phenotypes is found with cryptogenic cirrhosis and with chronic active hepatitis (CAH). Cirrhosis in a child should raise consideration of AAT deficiency or Wilson’s disease. Diagnosis of inflammatory states, if elevated, e.g., rheumatoid arthritis, bacterial infection, vasculitis and neoplasia.

Test Code

A1AS