Specimen Requirements
Title
Antiphospholipid Antibody Panel
Specimen Requirement
Collect 3 light blue sodium citrate tubes and centrifuge within 60 minutes. Using a plastic pipette transfer 1 mL plasma to 3 separate screw top transport tubes and indicate sample type on tubes.
Methodology
Immunoassay (IA)
Stability
Room temp: 5 days, Refrigerated: 14 days, Frozen: 30 days
Reference Range
By Report*
Turnaround
3-8 days
Clinical Use
Test includes:
Beta-2 Glycoprotein Ab (IgA, IgG, IgM)
Cardiolipin Ab (IgA, IgG, IgM)
Phosphatidylserine/Prothrombin (PS/PT) Ab (IgG, IgM)
The antiphospholipid antibody syndrome (APS) is a clinical-pathologic correlation that includes a clinical event (e.g. arterial or venous thrombosis, pregnancy morbidity) and persistent positive antiphospholipid antibodies (IgM, IgG Cardiolipin or b2GPI antibodies greater than the 99th percentile; or a lupus anticoagulant). International consensus guidelines for APS suggest waiting at least 12 weeks before retesting to confirm antibody persistence. Low level antiphospholipid antibodies may sometimes be detected in the setting of infection, drug therapy or aging.
Test Code
APLP