Antiphospholipid Antibody Panel
Collect 3 light blue tops, centrifuge within 60 minutes of collection. Using a plastic pipette transfer 1 mL each to 3 screw top transport tubes, indicate plasma/light blue on tube and send.
Room temp: 5 days, Refrigerated: 14 days, Frozen: 30 days
Test includes:Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM),Phosphatidylserine/Prothrombin (PS/PT) Antibodies (IgG, IgM) & Cardiolipin Antibodies (IgA, IgG, IgM)
The antiphospholipid antibody syndrome (APS) is a clinical-pathologic correlation that includes a clinical event (e.g. arterial or venous thrombosis, pregnancy morbidity) and persistent positive antiphospholipid antibodies (IgM, IgG Cardiolipin or b2GPI antibodies greater than the 99th percentile; or a lupus anticoagulant). International consensus guidelines for APS suggest waiting at least 12 weeks before retesting to confirm antibody persistence. The Systemic Lupus International Collaborating Clinics immunological classification criteria for systemic lupus erythematosus (SLE) include testing for isotype IgA, which has yet to be incorporated into APS criteria. Low level antiphospholipid antibodies may sometimes be detected in the setting of infection, drug therapy or aging.