Specimen Requirements


Cyclic Citrullinated Peptide, IgG/IgA AB (CCP)

Specimen Requirement

1 SST/1.0 mL (0.5 mL minimum) serum. After clotting, promptly centrifuge and refrigerate serum



Room Temp: 8 hours; Refrigerated: 48 hours; Frozen: 2 weeks

Reference Range

By Report*


3-5 days

Clinical Use

Cyclic Citrullinated Peptide (CCP) IgG Anitbody is better at discriminating rheumatoid arthritis (RA) patients than either the perinuclear autoantibody test or the test for rheumatoid factor. In published literature, approximately 70% of patients with RA are positive for anti-CCP IgG, while only about 2% of random blood donors and disease control subjects are positive. A recent study found citrullinated proteins in the joints of patients with RA, but not in patients with other forms of joint disease.

Test Code