Specimen Requirements


Fentanyl and Metabolite Serum

Specimen Requirement

Collect a red top or lavender EDTA, promptly centrifuge and transfer 2.0 mL serum or plasma to a plastic screw top tube, indicate serum/red top or plasma/lav top on tube and send.


High Performance Liquid Chromatography/Tandem Mass Spectrometry


Room temp: 14 days, Refrigerated: 30 days, Frozen: 10 months

Reference Range

By Report*


5-7 days

Clinical Use

Test includes: Fentanyl and Norfentanyl

To confirm or identify suspected drug toxicity in chronic use, therapeutic misadventure, or accidental or intentional acute overdose; to aid in the identification of an unknown drug ingested in unknown quantities, drug identification and/or quantitation may be performed as an adjunct for patient management; to monitor selected patient groups at greater risk for analgesic drug toxicity or drug-to-drug interaction; to confirm complete drug absorption and adequate drug elimination as an adjunct to overdose management.

Test Code