METHYLMALONIC ACID, SERUM
1 SST/1.0 mL serum. After 30 minutes of clotting, promptly centrifuge.
Room Temperature Unacceptable, Refrigerated 4 days, Frozen 14 days
1-3 DAYS -- PERFORMED MON, WED, THURS, FRI
Methylmalonic acid is a very sensitive indicator of Vitamin B12 deficiency at the tissue level. Mildly elevated levels (0.4-1.0 umol/L) are seen in patients with decreased renal function. Extremely high levels (>20 umol/L) are indicative of methylmalonic acidemia, an inborn error of metabolism disorder.