Smith Antibody (Anti-SM)
Collect SST/1.0 mL serum. After 30 minutes of clotting, promptly centrifuge and send refrigerated.
Alternate sample: Red top
Enzyme Linked Immunoassay
Room temp: 8 hours, Refrigerated: 7 days, Frozen: 14 days
1-3 days, Performed Mon-Fri
Anti-Sm antibodies offer a highly specific but relatively insensitive clinical marker of SLE. Their overall prevalence ranges from approximately 20-30% in SLE. Anti-Sm reactivity is not described definitively on other diseases, although a few studies describe Sm antibodies in monoclonal gammopathies and uveitis.