Specimen Requirements

Title

Smith Antibody (Anti-SM)

Specimen Requirement

Collect SST/1.0 mL serum. After 30 minutes of clotting, promptly centrifuge and send refrigerated.

Alternate sample: Red top

Methodology

Enzyme Linked Immunoassay

Stability

Room temp: 8 hours, Refrigerated: 7 days, Frozen: 14 days

Reference Range

By Report*

Turnaround

1-3 days, Performed Mon-Fri

Clinical Use

Anti-Sm antibodies offer a highly specific but relatively insensitive clinical marker of SLE. Their overall prevalence ranges from approximately 20-30% in SLE. Anti-Sm reactivity is not described definitively on other diseases, although a few studies describe Sm antibodies in monoclonal gammopathies and uveitis.

Test Code

SMABW