The combination of a Pap test and a high-risk HPV assay can be used screening of women over age 30 for cellular changes of the cervix. Knowing whether or not a woman is infected with high-risk HPV is added information that will help physicians detect and treat early cell changes that might eventually lead to cervical cancer. Both the Pap and high- risk HPV test results should be used along with a complete medical history and an evaluation of other risk factors to help physicians determine what kind of follow-up is necessary.