High values are reported with surgery or irradiation to the thyroid, with thyroiditis, T4-binding globulin deficiency, with administration of TRH, TSH, iodine, and with administration of anticancer drugs. High levels also occur in goiter and in many types of hyperthyroidism. Low values occur with thyroid hormone administration. The absence of thyroglobulin from the serum of neonates suggests congenital athyreosis. Thyroglobulin Autoantibodies can interfere with the determination of Thyroglobulin. If specimen contains Thyroglobulin Autoantibodies, interpret Thyroglobulin result with caution.