Specimen Requirements

Title

WELLBUTRIN (BUPROPION)

Specimen Requirement

Draw blood in a plain red-top. Spin, separate serum from cells ASAP or within 2 hours. Transfer 2.0ml serum to screw-capped plastic vial; write “serum/red top” on transport tube and freeze. Contact lab for dry ice for shipment; when dry ice is received, ship to lab.

Submit with order: Dose (list drug amount and include the units), Route (IV vs oral), Dose Frequency (per day/week or as needed) and Type of draw (peak, trough, random etc).

CRITICAL FROZEN

Methodology

Stability

Frozen 1 month *CRITICAL FROZEN*

Reference Range

By Report*

Turnaround

Performed Wed/Sat Reports in 3-7 days

Clinical Use

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause mental confusion, cardiac abnormalities and seizures. Concentrations below 25 ng/mL may have no effect. This method does not quantify the major metabolite, hydroxybupropion.

Test Code

BUP